In recent years, global political dynamics have experienced significant changes, influenced by the impact of the COVID-19 pandemic. This health crisis not only affects public health, but also accelerates changes in international relations, global economics, and political policies. First, one of the striking changes is the increase in nationalism in many countries. The pandemic has pushed countries to focus on domestic interests, which can be seen from policies closing borders, controlling vaccine distribution, and protecting local industry. Countries such as the United States and India demonstrate this tendency by prioritizing domestic interests over international collaboration. Second, the pandemic has exposed global inequalities even more starkly. Developing countries have difficulty getting access to vaccines and adequate health resources. This has sparked criticism of rich countries, which have predominantly secured vaccine doses for their own populations. These inequalities lead to critical reflection on the international system and spark debate about greater global justice. Third, the emergence of new powers in geopolitics is also in the spotlight. China, through the Belt and Road initiative and health diplomacy, is trying to strengthen its position on the international stage. This, on the one hand, creates tensions with countries like the US, which are trying to maintain their dominance in various arenas. These tensions are not only limited to the economic field, but also include technology and cyber security issues. Furthermore, climate change is becoming an increasingly urgent global political agenda. The pandemic shows that the health crisis and the climate crisis are closely related. Many countries are starting to link post-pandemic economic revival to the implementation of environmentally friendly policies. The Paris Agreement and its net-zero emissions target are becoming increasingly relevant in global political dialogue. Finally, digital transformation accelerated during the pandemic is changing the way diplomacy is conducted. Virtual meetings are becoming the norm, reducing the need for physical diplomatic travel. While it provides some benefits, such as reduced costs, it also brings new challenges, including cybersecurity issues. Overall, post-pandemic global political dynamics show greater complexity. Multilateral approaches and international cooperation are faced with new challenges, while core issues such as inequality, global health security and climate change increasingly demand attention. As the world adapts to this new reality, it is important to observe how countries will navigate collaborative challenges in this era of uncertainty.